The Affordable Care Act at 10 Years: Evaluating the Evidence and Navigating an Uncertain Future
type: Article
item type: journalArticle
is part of: Journal of Surgical Research
authors: Person
  surname: Neiman
  given name: Pooja U.
authors: Person
  surname: Tsai
  given name: Thomas C.
authors: Person
  surname: Bergmark
  given name: Regan W.
authors: Person
  surname: Ibrahim
  given name: Andrew
authors: Person
  surname: Nathan
  given name: Hari
authors: Person
  surname: Scott
  given name: John W.
is referenced by: doi: 10.1016/j.jss.2020.12.056
date: 2021-07-01
date submitted: 2024-10-31
description: Publisher: Elsevier
pages: 102-109

Journal of Surgical Research
type: Journal
volume: 263
identifier: DOI 10.1016/j.jss.2020.12.056
identifier: ISSN 0022-4804

doi: 10.1016/j.jss.2020.12.056
type: Memo

Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes.
type: Article
item type: journalArticle
is part of: Pediatric endocrinology, diabetes, and metabolism
authors: Person
  surname: Sokolewicz
  given name: Ewa M.
authors: Person
  surname: Dzwilewski
  given name: Kamil
authors: Person
  surname: Omieczyńska
  given name: Natalia
authors: Person
  surname: Zawadzka
  given name: Marta
authors: Person
  surname: Mazurkiewicz-Bełdzińska
  given name: Maria
link: PEDM_Art_53395-10.pdf
subject: *Diabetes Mellitus, Type 1/complications/drug therapy
subject: Blood Glucose/metabolism
subject: Child
subject: diabetes
subject: Drug Resistant Epilepsy/drug therapy/etiology
subject: encephalopathy
subject: epilepsy
subject: Humans
subject: hypoglycemia.
subject: Hypoglycemia/etiology
subject: Male
abstract: Hypoglycemic encephalopathy (HE) is a type of encephalopathy resulting from extremely low blood glucose level. Symptoms are not specific and can be misdiagnosed very often. It can occur during deep and/or prolonged hypoglycemia, which may be a result of inadequately controlled diabetes. Here, we report a case of an 11-year old male patient diagnosed with type 1 diabetes mellitus treated with the use of insulin pump who was admitted to the Pediatric Neurology Department because of multiple incidents of seizures. Boy was found unconscious by his mother. The blood glucose level on the glucometer was 35 mg/dl. It turned out that the reason of hypoglycemia was inadequate insulin dosing. He was given intravenous glucose by the ambulance service without improvement in the state of consciousness. Brain MRI revealed in both cerebral hemispheres, symmetrically, elevated white matter signal, mainly in the subcortex and cortex of the frontal and occipital and parietal lobes with features of diffusion restriction. EEG revealed generalized slow brain activity, without obvious epileptiform. Boy was provided with a variety of antiepileptic drugs. Unfortunately, none of them yielded with satisfactory results so far and the patient is still suffering from drug-resistant epilepsy. In conclusion, glucose is one of the key metabolic agents for the proper brain function and any imbalances in its blood level may impair the neuronal computation. Thus, it is extremely important, especially among diabetic patients, to control glucose blood level and avoid any disturbances, as they may lead to severe consequences, such as HE and drug-resistant epilepsy.
date: 2024
language: eng
description: Place: Poland PMID: 39026478 PMCID: PMC11037085
pages: 42-44

Pediatric endocrinology, diabetes, and metabolism
type: Journal
volume: 30
identifier: DOI 10.5114/pedm.2024.137890
number: 1
alternative: Pediatr Endocrinol Diabetes Metab
identifier: ISSN 2083-8441 2081-237X

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resource: PEDM Art 53395-10.pdf
link mode: 2
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Seizure occurrences among hypoglycemic patients in the emergency department
type: Article
item type: journalArticle
is part of: Acute Medicine & Surgery
authors: Person
  surname: Urushidani
  given name: Seigo
authors: Person
  surname: Tanabe
  given name: Mao
authors: Person
  surname: Baek
  given name: Kwangsoo
authors: Person
  surname: Miyaguchi
  given name: Koki
authors: Person
  surname: Ikegami
  given name: Tetsunori
link: AMS2-11-e979.pdf
abstract: Abstract Aim Symptomatic hypoglycemia is a common problem in the emergency department (ED). However, without appropriate recognition and management, hypoglycemia remains a potentially fatal condition. The cause of sudden death associated with hypoglycemia might be attributed to cardiac arrhythmias and hypoxia with seizures. Despite advances in diabetes mellitus management and social background, the frequency and characteristics of patients with hypoglycemia‐related seizures have remained unknown. Hence, our study aimed to investigate the frequency and characteristics of patients with hypoglycemia presenting with seizures in the ED. Methods This retrospective observational study was conducted in a single tertiary care center. Patient information was retrieved from the final diagnostic records in the ED. We reviewed all medical records and included patients with symptomatic hypoglycemia aged 16 years or older. The primary outcome was the frequency of seizures in patients with hypoglycemia. We also compared the initial blood sugar levels of the patients with and without seizures. Results We included a total of 380 patients (median age, 72 years, IQR 64–80 years; median initial blood sugar, 34 mg/dL, IQR 24–46; 62.9% male). Nineteen of 380 patients (5.0%) had seizures. Although 16 of the 19 patients had diabetes mellitus, none of the 19 patients had a history of epilepsy. The initial blood sugar levels of the patients with and without seizures were not significantly different ( p = 0.97). Conclusion Approximately 5% of the patients with hypoglycemia presented with seizures. Blood glucose levels of hypoglycemic patients with and without seizures did not differ.
date: 01/2024
language: en
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:12:38
pages: e979

Acute Medicine & Surgery
type: Journal
volume: 11
identifier: DOI 10.1002/ams2.979
number: 1
alternative: Acute Medicine & Surgery
identifier: ISSN 2052-8817, 2052-8817

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resource: AMS2-11-e979.pdf
link mode: 2
type: application/pdf

Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management
type: Article
item type: journalArticle
is part of: Frontiers in Neuroscience
authors: Person
  surname: Lipsky
  given name: Robert H.
authors: Person
  surname: Witkin
  given name: Jeffrey M.
authors: Person
  surname: Shafique
  given name: Hana
authors: Person
  surname: Smith
  given name: Jodi L.
authors: Person
  surname: Cerne
  given name: Rok
authors: Person
  surname: Marini
  given name: Ann M.
link: Full Text
abstract: Traumatic brain injury (TBI) has reached epidemic proportions worldwide. The consequences of TBI can be severe even with repetitive mild trauma. If death and coma are avoided, the consequences of TBI in the long term typically involve dizziness, sleep disturbances, headache, seizures, cognitive impairment, focal deficits, depression, and anxiety. The severity of brain injury is a significant predictor of outcome. However, the heterogenous nature of the injury makes prognosis difficult. The present review of the literature focuses on the genetics of TBI including genome wide (GWAS) data and candidate gene associations, among them brain-derived neurotrophic factor (BDNF) with TBI and development of post-traumatic epilepsy (PTE). Molecular biomarkers of TBI are also discussed with a focus on proteins and the inflammatory protein IL1-β. The secondary medical sequela to TBI of cognitive impairment, PTE, headache and risk for neurodegenerative disorders is also discussed. This overview of TBI concludes with a review and discussion of the medical management of TBI and the medicines used for and being developed at the preclinical and clinical stages for the treatment of TBI and its host of life-debilitating symptoms.
date: 2024-10-4
short title: Traumatic brain injury
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:15:03
pages: 1446076

Frontiers in Neuroscience
type: Journal
volume: 18
identifier: DOI 10.3389/fnins.2024.1446076
alternative: Front. Neurosci.
identifier: ISSN 1662-453X

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item type: attachment
resource: Lipsky et al. - 2024 - Traumatic brain injury molecular biomarkers, gene.pdf
date submitted: 2024-11-01 17:15:06
link mode: 1
type: application/pdf

Disney to Pixar Transition Causing Epilepsy: A Case Report of Reflex Epilepsy
type: Article
item type: journalArticle
is part of: Journal of Child Neurology
authors: Person
  surname: Bhargava
  given name: Disha
authors: Person
  surname: Devries
  given name: Seth P.
link: Bhargava and Devries - 2024 - Disney to Pixar Transition Causing Epilepsy A Cas.pdf
abstract: This case report describes a rare instance of reflex seizures in a 4-year-old boy with a complex medical history, including total anomalous pulmonary venous connection and developmental disabilities. The patient experienced seizures triggered exclusively by a specific visual stimulus: the transition scene from the Disney castle to the Pixar lamp in Disney-Pixar movies. Video electroencephalography (EEG) revealed biparasagittal rhythmic delta waves and diffuse slowing, suggesting parietal involvement and complex cortical processing. The findings highlight the individualized nature of reflex epilepsy and highlight the need for a nuanced understanding of specific seizure triggers. Effective management included avoiding the identified visual stimulus and adjusting medication based on the patient's response. This case emphasizes the intricate relationship between sensory processing and epileptogenic mechanisms, contributing to our knowledge of cortical excitability and guiding targeted treatment strategies for reflex seizures.
date: 2024-10-29
language: en
short title: Disney to Pixar Transition Causing Epilepsy
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:16:51
pages: 08830738241292652

Journal of Child Neurology
type: Journal
identifier: DOI 10.1177/08830738241292652
alternative: J Child Neurol
identifier: ISSN 0883-0738, 1708-8283

Bhargava and Devries - 2024 - Disney to Pixar Transition Causing Epilepsy A Cas.pdf
type: Attachment
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resource: Bhargava and Devries - 2024 - Disney to Pixar Transition Causing Epilepsy A Cas.pdf
type: application/pdf

Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation—Structured Literature Review and Analysis
type: Article
item type: journalArticle
is part of: Journal of Xenobiotics
authors: Person
  surname: Dobravc Verbič
  given name: Matej
authors: Person
  surname: Grabnar
  given name: Iztok
authors: Person
  surname: Eyer
  given name: Florian
authors: Person
  surname: Brvar
  given name: Miran
link: Full Text
abstract: Over the past decade, quetiapine has become one of the most commonly used psychotropic drugs in acute intoxication events worldwide. A structured literature review and analysis were conducted to assess the relationship between the kinetic and dynamic profiles in acute quetiapine intoxication. The correlation between dose and peak serum concentration (cmax) was determined using Pearson’s correlation coefficient. Binary logistic regression was used to evaluate dose and cmax as predictors of the most common clinical events, signs and symptoms. One hundred and thirty-four cases of acute quetiapine ingestion were included in the analysis, with a median ingested dose of 10 g and a median cmax of 4 mg/L. The typical half-life was estimated to be 16.5 h, significantly longer than at therapeutic doses. For the immediate-release formulation, a biphasic disposition could not be excluded. Dose and cmax demonstrated a weak but significant correlation (r = 0.256; N = 63; p = 0.043). Central nervous system depression and tachycardia were the most common clinical signs. Higher doses and concentrations increased the risk of severe intoxication and were good predictors of intubation, tachycardia, hypotension, QTc prolongation and seizures, but not QRS prolongation, arrhythmia, heart block, hypokalaemia or acidosis. The thresholds for dose and cmax that increased the risk for individual signs and symptoms varied widely. However, doses > 3 g or cmax > 2 mg/L can be considered as alert levels that represent a high risk for severe clinical course of acute quetiapine intoxication.
date: 2024-10-18
language: en
short title: Acute Quetiapine Intoxication
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:24:57
rights: https://creativecommons.org/licenses/by/4.0/
pages: 1570-1594

Journal of Xenobiotics
type: Journal
volume: 14
identifier: DOI 10.3390/jox14040085
number: 4
alternative: JoX
identifier: ISSN 2039-4713

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type: Attachment
item type: attachment
resource: Dobravc Verbič et al. - 2024 - Acute Quetiapine Intoxication Relationship Betwee.pdf
date submitted: 2024-11-01 17:25:00
link mode: 1
type: application/pdf

Imipenem-Cilastatin-Induced Seizures: A Case Report
type: Article
item type: journalArticle
is part of: Current Drug Safety
authors: Person
  surname: Aloui
  given name: Ghaith
authors: Person
  surname: Houria
  given name: Baraa Ben
authors: Person
  surname: Yousfi
  given name: Mohamed Ali
link: Aloui et al. - 2024 - Imipenem-Cilastatin-Induced Seizures A Case Repor.pdf
abstract: Background: Imipenem-cilastatin, a carbapenem antibiotic, is commonly used for severe bacterial infections. While generally well-tolerated, it can rarely cause central nervous system toxicity, including seizures. We have, herein, reported a case of imipenem-cilastatin-induced seizure in a 20-year-old patient. Case Presentation: A 20-year-old male was admitted to the intensive care unit for febrile status epilepticus and acute respiratory distress syndrome. Initial evaluations ruled out underlying causes and anti-epileptic treatment has been initiated. Despite having an effective anti-epileptic treatment for three months of hospitalization, seizure recurrence occurred, leading to antibiotic regimen adjustment as the imputability of imipenem-cilastatin was suspected. After discontinuation of the involved drug, the patient remained neurologically stable. Previous literature has reported cases of imipenem-cilastatin-induced seizures, particularly in elderly patients or at higher dosages. The causality assessment was conducted using the updated French method, which rated the chronological criterion as C2 and the semiological criterion as S2. The intrinsic imputability score was I3, indicating plausible causality, and the extrinsic bibliographic score was B3. Conclusion: Our case has highlighted the importance of promptly recognizing imipenem-cilastatin- induced epileptic seizures in order to treat them more effectively and thus optimize the patient’s care. Therefore, we emphasize that clinicians be vigilant about the side effects of its use, particularly in patients with neurological susceptibilities. We also advocate a personalized choice of antibiotics, taking into account both antimicrobial efficacy and potential adverse effects, for better outcomes with fewer risks.
date: 2024-10-07
language: en
short title: Imipenem-Cilastatin-Induced Seizures
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:27:02

Current Drug Safety
type: Journal
volume: 19
identifier: DOI 10.2174/0115748863324094240919114700
alternative: CDS
identifier: ISSN 15748863

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type: Attachment
item type: attachment
resource: Aloui et al. - 2024 - Imipenem-Cilastatin-Induced Seizures A Case Repor.pdf
type: application/pdf

Fluoroquinolones and the risk for incidental seizures: a comparative retrospective study
type: Article
item type: journalArticle
is part of: Journal of Antimicrobial Chemotherapy
authors: Person
  surname: Gueta
  given name: Itai
authors: Person
  surname: Yonath
  given name: Hagith
authors: Person
  surname: Fluss
  given name: Ronen
authors: Person
  surname: Oberman
  given name: Bernice
authors: Person
  surname: Oppenheim
  given name: Amit
authors: Person
  surname: Ozeri
  given name: David
authors: Person
  surname: Kreiss
  given name: Yitshak
authors: Person
  surname: Loebstein
  given name: Ronen
link: Gueta et al. - 2024 - Fluoroquinolones and the risk for incidental seizu.pdf
abstract: Abstract Background Over the years, reports have associated fluoroquinolones (FQ) with seizures. The incidence and whether FQ compared to non-epileptogenic antibiotic are associated with increased risk of seizures has yet to be examined. Methods A retrospective observational study of hospitalized patients treated with FQ (ofloxacin, ciprofloxacin, levofloxacin, moxifloxacin) or macrolides (MA: azithromycin or roxithromycin) between January 2009 and January 2021 in a large tertiary academic medical centre. The outcome was the occurrence of a seizure during treatment. The Naranjo scale was used to assess causality between FQ treatment and seizures. Comparative analysis was conducted using propensity score matching to correct for possible bias due to non-random selection, followed by inverse probability weighting (IPW) to estimate the difference in seizure risk between FQ and MA. Results Overall, 52 722 patients were treated with FQ during a total of 178 982 days. Mean age was 65 (±19) years and 47% were females. Thirty-three patients (0.06%) experienced a seizure, yielding an incidence of 1:5422 treatment days. Causality was deemed probable and possible among 9/33 and 24/33, respectively. The MA group composed of 8522 patients treated during 17 954 treatment days. Mean age was 65 (±21) years, 49% were females. Six (0.07%) patients experienced each a single seizure. IPW estimated OR for seizures among the FQ versus MA group was 1.44 (95%CI 0.59–3.5, P = 0.42). Discussion The incidence of FQ associated seizures among hospitalized patients is low and the risk did not significantly exceed that under macrolides. Our results provide evidence for clinicians and decision-makers when balancing fluoroquinolones risks and benefits.
date: 2024-10-01
language: en
short title: Fluoroquinolones and the risk for incidental seizures
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:29:27
rights: https://academic.oup.com/pages/standard-publication-reuse-rights
pages: 2554-2560

Journal of Antimicrobial Chemotherapy
type: Journal
volume: 79
identifier: DOI 10.1093/jac/dkae255
number: 10
identifier: ISSN 0305-7453, 1460-2091

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resource: Gueta et al. - 2024 - Fluoroquinolones and the risk for incidental seizu.pdf
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Antibiotic-induced neuropsychiatric toxicity: epidemiology, mechanisms and management strategies –a narrative literature review
type: Article
item type: journalArticle
is part of: Drugs in Context
authors: Person
  surname: Althubyani
  given name: Ali A
authors: Person
  surname: Canto
  given name: Samantha
authors: Person
  surname: Pham
  given name: Huy
authors: Person
  surname: Holger
  given name: Dana J
authors: Person
  surname: Rey
  given name: Jose
link: Althubyani et al. - 2024 - Antibiotic-induced neuropsychiatric toxicity epid.pdf
subject: abx
date: 2024-07-24
short title: Antibiotic-induced neuropsychiatric toxicity
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:30:58
pages: 1-18

Drugs in Context
type: Journal
volume: 13
identifier: DOI 10.7573/dic.2024-3-3
alternative: DIC
identifier: ISSN 17404398

Althubyani et al. - 2024 - Antibiotic-induced neuropsychiatric toxicity epid.pdf
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item type: attachment
resource: Althubyani et al. - 2024 - Antibiotic-induced neuropsychiatric toxicity epid.pdf
type: application/pdf

Cefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit
type: Article
item type: journalArticle
is part of: Journal of Investigative Medicine High Impact Case Reports
authors: Person
  surname: Alagha
  given name: Zakaria
authors: Person
  surname: Crow
  given name: Samuel
authors: Person
  surname: Abdeen
  given name: Abdul Muhsen Z.
authors: Person
  surname: Alastal
  given name: Maha
authors: Person
  surname: Alastal
  given name: Amro
link: Full Text
abstract: Cefepime is a fourth-generation cephalosporin with extended antimicrobial coverage. Concerns have been raised about the side effects of cefepime including myoclonus, encephalopathy, and seizures, especially when renal impairment is present. There have been reports of cases of adverse neurological consequences despite appropriate renal adjustment. Here, we present a case of a 69-year-old patient initially diagnosed with pneumonia and treated with cefepime. The patient later developed altered mental status, leading to differential diagnoses including stroke, drug overdose, or non-convulsive seizures. Following a comprehensive workup, it was determined that she had cefepime-induced encephalopathy, despite having normal kidney function, which resolved completely after discontinuing the medication. In addition, we include similar cases retrieved from PubMed up to the present date, to the best of our knowledge.
date: 01/2024
language: en
short title: Cefepime Neurotoxicity in Patients With Normal Renal Function
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:33:09
pages: 23247096241259534

Journal of Investigative Medicine High Impact Case Reports
type: Journal
volume: 12
identifier: DOI 10.1177/23247096241259534
alternative: Journal of Investigative Medicine High Impact Case Reports
identifier: ISSN 2324-7096, 2324-7096

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type: Attachment
item type: attachment
resource: Alagha et al. - 2024 - Cefepime Neurotoxicity in Patients With Normal Ren.pdf
date submitted: 2024-11-01 17:33:10
link mode: 1
type: application/pdf

Clinical characteristics of seizure recurrence and epilepsy development in patients with alcohol‐related seizures
type: Article
item type: journalArticle
is part of: Alcohol, Clinical and Experimental Research
authors: Person
  surname: Chun
  given name: Min Young
authors: Person
  surname: An
  given name: Hyungmi
authors: Person
  surname: Lee
  given name: Hye Ah
authors: Person
  surname: Hwang
  given name: Sungeun
authors: Person
  surname: Chung
  given name: Seungwon
authors: Person
  surname: Kim
  given name: Na‐Young
authors: Person
  surname: Lee
  given name: Hyang Woon
link: Full Text
abstract: Abstract Background Alcohol withdrawal is widely recognized as a trigger for acute symptomatic seizures among individuals with chronic alcohol consumption. While most alcohol withdrawal seizures occur shortly after cessation, chronic alcohol consumption can be associated with the development of epilepsy, necessitating anti‐epileptic drug (AED) therapy. This study aimed to investigate the clinical characteristics, seizure recurrence, and epilepsy development in patients with alcohol‐related seizures and to identify prognostic factors for epilepsy. Methods In a retrospective analysis at Ewha Womans University Mokdong Hospital, 206 patients with alcohol‐related seizures were examined and 15 were excluded due to preexisting epilepsy. Demographic and clinical data, including alcohol withdrawal duration, seizure recurrence, types, and comorbidities, were investigated. Logistic regression models were used to analyze the risk factors for seizure recurrence and epilepsy development. The performance of the final models was evaluated based on the area under the receiver operating characteristic curve (AUC) and validated using calibration plots and leave‐one‐out cross‐validation. Results Of the 191 patients (146 males; mean age 48.3 ± 12.1 years) with alcohol‐related seizures, 99 patients (51.8%) experienced seizure recurrence and 79 patients (41.4%) developed epilepsy. Factors associated with seizure recurrence included alcohol consumption levels, occurrence of focal impaired awareness seizure, anxiety, and headache. The number of recurrent seizures, semiology, status epilepticus, electroencephalogram findings, and brain imaging findings was associated with epilepsy development. The predictive models showed strong diagnostic performance, with AUCs of 0.833 for seizure recurrence and 0.939 for epilepsy development. Conclusion High alcohol consumption and specific clinical and diagnostic features are significant predictors of seizure recurrence and the development of epilepsy am…
date: 2024-09-27
language: en
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:35:21
pages: acer.15449

Alcohol, Clinical and Experimental Research
type: Journal
identifier: DOI 10.1111/acer.15449
alternative: Alcohol, Clinical and Experimental Research
identifier: ISSN 2993-7175, 2993-7175

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type: Attachment
item type: attachment
resource: Chun et al. - 2024 - Clinical characteristics of seizure recurrence and.pdf
date submitted: 2024-11-01 17:35:27
link mode: 1
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Subacute encephalopathy with seizures in alcoholics (SESA) syndrome: Relevant questions
type: Article
item type: journalArticle
is part of: Epilepsy & Behavior
authors: Person
  surname: Fernández-Torre
  given name: José L.
authors: Person
  surname: Kaplan
  given name: Peter W.
authors: Person
  surname: Hernández-Hernández
  given name: Miguel A.
link: Fernández-Torre et al. - 2024 - Subacute encephalopathy with seizures in alcoholic.pdf
date: 10/2024
language: en
short title: Subacute encephalopathy with seizures in alcoholics (SESA) syndrome
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:37:12
pages: 109968

Epilepsy & Behavior
type: Journal
volume: 159
identifier: DOI 10.1016/j.yebeh.2024.109968
alternative: Epilepsy & Behavior
identifier: ISSN 15255050

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item type: attachment
resource: Fernández-Torre et al. - 2024 - Subacute encephalopathy with seizures in alcoholic.pdf
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Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data?
type: Article
item type: journalArticle
is part of: International Journal of Molecular Sciences
authors: Person
  surname: Miziak
  given name: Barbara
authors: Person
  surname: Błaszczyk
  given name: Barbara
authors: Person
  surname: Chrościńska-Krawczyk
  given name: Magdalena
authors: Person
  surname: Czuczwar
  given name: Stanisław J.
link: Full Text
abstract: Experimental studies reveal that caffeine (trimethylxanthine) at subconvulsive doses, distinctly reduced the anticonvulsant activity of numerous antiseizure medications (ASMs) in rodents, oxcarbazepine, tiagabine and lamotrigine being the exceptions. Clinical data based on low numbers of patients support the experimental results by showing that caffeine (ingested in high quantities) may sharply increase seizure frequency, considerably reducing the quality of patients’ lives. In contrast, this obviously negative activity of caffeine was not found in clinical studies involving much higher numbers of patients. ASMs vulnerable to caffeine in experimental models of seizures encompass carbamazepine, phenobarbital, phenytoin, valproate, gabapentin, levetiracetam, pregabalin and topiramate. An inhibition of R-calcium channels by lamotrigine and oxcarbazepine may account for their resistance to the trimethylxanthine. This assumption, however, is complicated by the fact that topiramate also seems to be a blocker of R-calcium channels. A question arises why large clinical studies failed to confirm the results of experimental and case-report studies. A possibility exists that the proportion of patients taking ASMs resistant to caffeine may be significant and such patients may be sufficiently protected against the negative activity of caffeine.
date: 2023-12-17
language: en
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:39:29
rights: https://creativecommons.org/licenses/by/4.0/
pages: 17569

International Journal of Molecular Sciences
type: Journal
volume: 24
identifier: DOI 10.3390/ijms242417569
number: 24
alternative: IJMS
identifier: ISSN 1422-0067

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item type: attachment
resource: Miziak et al. - 2023 - Caffeine and Its Interactions with Antiseizure Med.pdf
date submitted: 2024-11-01 17:39:31
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type: application/pdf

Seizures provoked by over-the-counter cough and cold medications in an elderly patient: a case report
type: Article
item type: journalArticle
is part of: Journal of Medical Case Reports
authors: Person
  surname: Alattiya
  given name: Mohammed Kays
authors: Person
  surname: Joudeh
  given name: Anwar I.
authors: Person
  surname: Hammamy
  given name: Riyadh Ali
is referenced by: caffice eldery
link: Full Text
abstract: Abstract Background Seizures are common neurological emergencies in the elderly that are frequently provoked. Geriatrics have higher rates of neurological disorders and other comorbidities that could affect seizure threshold. Case presentation An 83-year-old male Arabic patient presented to the emergency department with an acute confusional state and urinary incontinence followed by a witnessed tonic–clonic seizure in the hospital. Thorough investigations and imaging were positive only for nonspecific magnetic resonant imaging findings with a negative electroencephalogram. The patient was diagnosed with provoked seizure due to over-the-counter cold medications that included pseudoephedrine and caffeine. He was not prescribed antiepileptic medications at discharge and did not develop subsequent seizures up to this date. Conclusion Over-the-counter cough and cold medications with sympathomimetic ingredients can be associated with provoked seizures in the elderly. Physicians should be aware of the potentially serious adverse events associated with commonly used nonprescription sympathomimetics such as pseudoephedrine and caffeine in elderly patients.
date: 2023-04-29
language: en
short title: Seizures provoked by over-the-counter cough and cold medications in an elderly patient
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:41:16
pages: 170

Journal of Medical Case Reports
type: Journal
volume: 17
identifier: DOI 10.1186/s13256-023-03912-2
number: 1
alternative: J Med Case Reports
identifier: ISSN 1752-1947

caffice eldery
type: Memo

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type: Attachment
item type: attachment
resource: Alattiya et al. - 2023 - Seizures provoked by over-the-counter cough and co.pdf
date submitted: 2024-11-01 17:41:18
link mode: 1
type: application/pdf

Caffeine exacerbates seizure-induced death via postictal hypoxia
type: Article
item type: journalArticle
is part of: Scientific Reports
authors: Person
  surname: George
  given name: Antis G.
authors: Person
  surname: Federico
  given name: Alyssa
authors: Person
  surname: Gom
  given name: Renaud C.
authors: Person
  surname: Harris
  given name: Sydney A.
authors: Person
  surname: Teskey
  given name: G. Campbell
link: Full Text
abstract: Abstract Sudden unexpected death in epilepsy (SUDEP) is the leading epilepsy-related cause of premature mortality in people with intractable epilepsy, who are 27 times more likely to die than the general population. Impairment of the central control of breathing following a seizure has been identified as a putative cause of death, but the mechanisms underlying this seizure-induced breathing failure are largely unknown. Our laboratory has advanced a vascular theory of postictal behavioural dysfunction, including SUDEP. We have recently reported that seizure-induced death occurs after seizures invade brainstem breathing centres which then leads to local hypoxia causing breathing failure and death. Here we investigated the effects of caffeine and two adenosine receptors in two models of seizure-induced death. We recorded local oxygen levels in brainstem breathing centres as well as time to cessation of breathing and cardiac activity relative to seizure activity. The administration of the non-selective A 1 /A 2A antagonist caffeine or the selective A 1 agonist N6-cyclopentyladenosine reveals a detrimental effect on postictal hypoxia, providing support for caffeine modulating cerebral vasculature leading to brainstem hypoxia and cessation of breathing. Conversely, A 2A activation with CGS-21680 was found to increase the lifespan of mice in both our models of seizure-induced death.
date: 2023-08-29
language: en
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:42:05
pages: 14150

Scientific Reports
type: Journal
volume: 13
identifier: DOI 10.1038/s41598-023-41409-6
number: 1
alternative: Sci Rep
identifier: ISSN 2045-2322

Full Text
type: Attachment
item type: attachment
resource: George et al. - 2023 - Caffeine exacerbates seizure-induced death via pos.pdf
date submitted: 2024-11-01 17:42:09
link mode: 1
type: application/pdf

Hypocalcemia‐induced seizures in a peritoneal dialysis ( PD ) patient: A case report
type: Article
item type: journalArticle
is part of: Clinical Case Reports
authors: Person
  surname: Taha
  given name: Mohammed
authors: Person
  surname: Azhary
  given name: Ayman
authors: Person
  surname: Ahmed
  given name: Abdallah Elssir
authors: Person
  surname: Abdelbagi
  given name: Abubakar
authors: Person
  surname: Hamida
  given name: Mohammed Elfatih
authors: Person
  surname: Ournasseir
  given name: Mohammed Elfatih Hussein
link: Taha et al. - 2024 - Hypocalcemia‐induced seizures in a peritoneal dial.pdf
abstract: Key Clinical Message A thorough evaluation is necessary for seizures caused by hypocalcemia, both during the patient's presentation and following their recovery from the postictal seizure episode. This is because the underlying cause of hypocalcemia must be ruled out in order to ensure the best possible clinical outcome from calcium and vitamin D therapy. Abstract Patients with multiple systemic issues, including neurological involvement and seizure development, are not uncommon among nephrologists. Both the central and peripheral neural systems can be impacted by kidney disease. The main symptoms are myopathy, cranial or peripheral neuropathy, cognitive impairment, and seizures. A 22‐year‐old female with an unusual medical history who had been known to have end‐stage kidney disease (ESKD) for a year and regularly had CAPD (continuous ambulatory peritoneal dialysis) suffered from two episodes of tonic‐colonic seizures 2 weeks apart. On physical examination, symptoms of tongue biting, decreased vision in the left eye, and mild bilateral pulmonary air entry were notable. Upon examination, there was evidence of severe hypocalcemia, hyponatremia, a high renal profile (urea and creatinine), anemia, and a severe vitamin D deficiency. Her peritoneal dialysis (PD) prescription was reviewed, her seizures ceased, and she was released from the hospital after the hypocalcemia was treated with intravenous calcium and high doses of vitamin D. The issue of hypocalcemic seizures should be carefully evaluated both at the presentation and after the patient recovers from the postictal stage. By following this, seizure episodes can be prevented with good success if patients strictly adhere to the medication for which they are responsible.
date: 10/2024
language: en
short title: Hypocalcemia‐induced seizures in a peritoneal dialysis ( <span style="font-variant
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:44:45
pages: e9477

Clinical Case Reports
type: Journal
volume: 12
identifier: DOI 10.1002/ccr3.9477
number: 10
alternative: Clinical Case Reports
identifier: ISSN 2050-0904, 2050-0904

Taha et al. - 2024 - Hypocalcemia‐induced seizures in a peritoneal dial.pdf
type: Attachment
item type: attachment
resource: Taha et al. - 2024 - Hypocalcemia‐induced seizures in a peritoneal dial.pdf
type: application/pdf

Association of dietary fiber intake with epileptic seizures in U.S. adults: A Population-base study of 13,277 participants
type: Article
item type: journalArticle
is part of: Seizure: European Journal of Epilepsy
authors: Person
  surname: Zhang
  given name: Yi-Bin
authors: Person
  surname: Xu
  given name: Ye
authors: Person
  surname: Zheng
  given name: Shu-Fa
authors: Person
  surname: Lin
  given name: Yuan-Xiang
authors: Person
  surname: Kang
  given name: De-Zhi
authors: Person
  surname: Yao
  given name: Pei-Sen
link: Zhang et al. - 2024 - Association of dietary fiber intake with epileptic.pdf
date: 11/2024
language: en
short title: Association of dietary fiber intake with epileptic seizures in U.S. adults
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:45:58
pages: 1-9

Seizure: European Journal of Epilepsy
type: Journal
volume: 122
identifier: DOI 10.1016/j.seizure.2024.09.005
alternative: Seizure: European Journal of Epilepsy
identifier: ISSN 10591311

Zhang et al. - 2024 - Association of dietary fiber intake with epileptic.pdf
type: Attachment
item type: attachment
resource: Zhang et al. - 2024 - Association of dietary fiber intake with epileptic.pdf
type: application/pdf

Clinical characteristics and serum 25-hydroxyvitamin D levels in children with febrile seizures in China
type: Article
item type: journalArticle
is part of: Scientific Reports
  type: Journal
  volume: 14
  identifier: DOI 10.1038/s41598-024-73850-6
  number: 1
  alternative: Sci Rep
  identifier: ISSN 2045-2322
authors: Person
  surname: Zhang
  given name: Li
authors: Person
  surname: Lin
  given name: Xi
authors: Person
  surname: Liu
  given name: Bin
authors: Person
  surname: Liu
  given name: Qing
link: Full Text
date: 2024-10-07
language: en
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:48:15
pages: 23330

Full Text
type: Attachment
item type: attachment
resource: Zhang et al. - 2024 - Clinical characteristics and serum 25-hydroxyvitam.pdf
date submitted: 2024-11-01 17:48:17
link mode: 1
type: application/pdf

Febrile Seizures, Ongoing Epileptiform Activity, and the Resulting Long-Term Consequences: Lessons From Animal Models
type: Article
item type: journalArticle
is part of: Pediatric Neurology
authors: Person
  surname: Harris
  given name: Sydney A.
authors: Person
  surname: Gordon
  given name: Emily E.
authors: Person
  surname: Barrett
  given name: Karlene T.
authors: Person
  surname: Scantlebury
  given name: Morris H.
authors: Person
  surname: Teskey
  given name: G. Campbell
link: Harris et al. - 2024 - Febrile Seizures, Ongoing Epileptiform Activity, a.pdf
date: 12/2024
language: en
short title: Febrile Seizures, Ongoing Epileptiform Activity, and the Resulting Long-Term Consequences
library catalog: DOI.org (Crossref)
date submitted: 2024-11-01 17:48:34
pages: 216-222

Pediatric Neurology
type: Journal
volume: 161
identifier: DOI 10.1016/j.pediatrneurol.2024.09.026
alternative: Pediatric Neurology
identifier: ISSN 08878994

Harris et al. - 2024 - Febrile Seizures, Ongoing Epileptiform Activity, a.pdf
type: Attachment
item type: attachment
resource: Harris et al. - 2024 - Febrile Seizures, Ongoing Epileptiform Activity, a.pdf
type: application/pdf

A Very Rare Side Effect of a Very Commonly Used Drug: Pantoprazole-induced Seizure
type: Article
item type: journalArticle
is part of: The Journal of the Association of Physicians of India
authors: Person
  surname: Anandan
  given name: Somarajan
authors: Person
  surname: Rajendran
  given name: Sajeesh S.
authors: Person
  surname: Somarajan
  given name: Sourav Asha
authors: Person
  surname: Udayan
  given name: Archana
is referenced by: hypi cacalcemia and hypomagnesia
link: PubMed entry
subject: 2-Pyridinylmethylsulfinylbenzimidazoles
subject: Humans
subject: Hypocalcemia
subject: Hypokalemia
subject: Magnesium Deficiency
subject: Male
subject: Middle Aged
subject: Pantoprazole
subject: Proton Pump Inhibitors
subject: Seizures
abstract: Pantoprazole is an extensively used proton pump inhibitor (PPI) for acid peptic disease. PPI rarely cause hypomagnesemia. Hypomagnesemia is commonly associated with hypokalemia and hypocalcemia. Severe hypomagnesemia and hypocalcemia can cause seizures. Here, we report a patient on long-term pantoprazole who presented with generalized tonic-clonic seizures and had severe hypomagnesemia, hypocalcemia, hypokalemia, and secondary hyperparathyroidism. When patients on long-term PPI present with seizures, hypomagnesemia/hypocalcemia has to be excluded.
date: 2024-08
language: eng
short title: A Very Rare Side Effect of a Very Commonly Used Drug
library catalog: PubMed
description: PMID: 39163076
pages: 89

The Journal of the Association of Physicians of India
type: Journal
volume: 72
identifier: DOI 10.59556/japi.72.0579
number: 8
alternative: J Assoc Physicians India
identifier: ISSN 0004-5772

hypi cacalcemia and hypomagnesia
type: Memo

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-01 17:51:17
link mode: 3
type: text/html

Vitamin B12 Deficiency Newborn Screening
type: Article
item type: journalArticle
is part of: Pediatrics
authors: Person
  surname: Mütze
  given name: Ulrike
authors: Person
  surname: Gleich
  given name: Florian
authors: Person
  surname: Haas
  given name: Dorothea
authors: Person
  surname: Urschitz
  given name: Michael S.
authors: Person
  surname: Röschinger
  given name: Wulf
authors: Person
  surname: Janzen
  given name: Nils
authors: Person
  surname: Hoffmann
  given name: Georg F.
authors: Person
  surname: Garbade
  given name: Sven F.
authors: Person
  surname: Syrbe
  given name: Steffen
authors: Person
  surname: Kölker
  given name: Stefan
link: PubMed entry
subject: Female
subject: Germany
subject: Humans
subject: Infant
subject: Infant, Newborn
subject: Male
subject: Neonatal Screening
subject: Prospective Studies
subject: Vitamin B 12 Deficiency
abstract: BACKGROUND: Vitamin B12 deficiency (VitB12D) might cause neuro-developmental impairment in the first year of life. Newborn screening (NBS) for VitB12D was shown to be technically feasible and early treated infants developed favorably. This study aims to evaluate the impact of NBS in prevention of symptomatic infantile VitB12D. METHODS: In a nationwide surveillance study in cooperation with the German Pediatric Surveillance Unit, incident cases with VitB12D (<12 months of age) were prospectively collected from 2021 to 2022. RESULTS: In total, 61 cases of VitB12D reported to German Pediatric Surveillance Unit were analyzed, either identified by NBS (N = 31) or diagnosed after the onset of suggestive symptoms (non-NBS; N = 30). Ninety percent of the infants identified by NBS were still asymptomatic, whereas the non-NBS cohort presented at median 4 month of age with muscular hypotonia (68%), anemia (58%), developmental delay (44%), microcephalia (30%), and seizures (12%). Noteworthy, symptomatically diagnosed VitB12D in the first year of life was reported 4 times more frequently in infants who did not receive NBS for neonatal VitB12D (14 in 584 800) compared with those screened for VitB12D as newborns (4 in 688 200; Fisher's Exact Test, odds ratio 4.12 [95% confidence interval: 1.29-17.18], P = .008). The estimated overall cumulative incidence was 1:9600 newborns per year for neonatal VitB12D and 1:17 500 for symptomatic infantile VitB12D. CONCLUSIONS: NBS for neonatal VitB12D may lead to a fourfold risk reduction of developing symptomatic VitB12D in the first year of life compared with infants without NBS.
date: 2024-08-01
language: eng
library catalog: PubMed
description: PMID: 39040028
pages: e2023064809

Pediatrics
type: Journal
volume: 154
identifier: DOI 10.1542/peds.2023-064809
number: 2
alternative: Pediatrics
identifier: ISSN 1098-4275

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-01 17:53:02
link mode: 3
type: text/html

Seizure and Takotsubo Cardiomyopathy Due to Proton Pump Inhibitor
type: Article
item type: journalArticle
is part of: Journal of Community Hospital Internal Medicine Perspectives
authors: Person
  surname: Acharya
  given name: Indira
authors: Person
  surname: Pokharel
  given name: Ashik
authors: Person
  surname: Grove
  given name: Daniel A.
authors: Person
  surname: Haas
  given name: Christopher J.
is referenced by: electrolyte info
link: Full Text
link: PubMed entry
subject: Electrolyte abnormalities
subject: Histamine-2 receptor antagonists
subject: Hypomagnesemia
subject: Proton pump inhibitor
subject: Seizure
subject: Takotsubo cardiomyopathy
abstract: Proton Pump Inhibitor (PPI)-induced hypomagnesemia, first described in 2006, has gained increasing recognition in recent years as a potentially life-threatening adverse event. In comparison to histamine-2 receptor antagonists (H2RA), PPIs exhibit a higher frequency of electrolyte abnormalities, including hypomagnesemia, hypocalcemia, hypokalemia, and hyponatremia; hypomagnesemia is the most common. We report a case of an 80-year-old woman who presented with generalized weakness and diarrhea. She was found to have multiple electrolyte abnormalities that failed to resolve even after the resolution of diarrhea and resumption of feeding. However, her condition improved within one week of discontinuing PPI medication. Her hospital course was complicated by a seizure, attributed to alterations in ionic gradients across cellular membranes affecting neuronal discharge and facilitating epileptiform activities. Additionally, she experienced Takotsubo cardiomyopathy due to decreased myocardial contractility, both in the context of electrolyte imbalance induced by prolonged PPI use.
date: 2024
language: eng
library catalog: PubMed
description: PMID: 39391120 PMCID: PMC11464067
pages: 114-117

Journal of Community Hospital Internal Medicine Perspectives
type: Journal
volume: 14
identifier: DOI 10.55729/2000-9666.1360
number: 4
alternative: J Community Hosp Intern Med Perspect
identifier: ISSN 2000-9666

electrolyte info
type: Memo

Full Text
type: Attachment
item type: attachment
resource: Acharya et al. - 2024 - Seizure and Takotsubo Cardiomyopathy Due to Proton.pdf
date submitted: 2024-11-01 17:54:05
link mode: 1
type: application/pdf

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-01 17:54:04
link mode: 3
type: text/html

Proton Pump Inhibitor Induced Hypomagnesemia Causing Seizures: A Rare Adverse Effect of a Commonly Used Medication
type: Article
item type: journalArticle
is part of: Cureus
authors: Person
  surname: Krishnan
  given name: Manojkumar
authors: Person
  surname: Fernando
  given name: Hiruni
authors: Person
  surname: Mohammed
  given name: Hassan H.
authors: Person
  surname: Vithanage
  given name: Neranjana
is referenced by: hypomagnesemia
link: Full Text
link: PubMed entry
subject: etiology of hypomagnesemia
subject: hypomagnesemia
subject: intestinal magnesium loss
subject: proton pump inhibitors (ppi)
subject: serum magnesium
abstract: Hypomagnesemia is defined as serum magnesium levels less than 0.7mmol/L and can result in a plethora of symptoms ranging from mild gastrointestinal symptoms to serious conditions such as cardiac arrhythmias and neurological complications. When considering the etiological factors, drug-induced hypomagnesemia is highlighted because commonly used medications such as proton pump inhibitors (PPIs), aminoglycoside antibiotics, and loop and thiazide diuretics can cause low magnesium levels. A 49-year-old male presented to the emergency department with severe vomiting worsening over three days complicated with generalized tonic-clonic seizures. He was an averagely built male, a non-smoker, and a non-alcoholic with no significant co-morbidities. He had a history of chronic over-the-counter pantoprazole intake over the last one year, and apart from that, his medication history was unremarkable. Initial investigations revealed severe hypomagnesemia (with serum magnesium level of 0.1mmol/L), with marginal hypokalemia, hypophosphatemia, and hypocalcemia. Following the initial resuscitation and magnesium supplementation, the patient's clinical condition significantly improved. Due to the lack of proper knowledge, the patient continued to take omeprazole 20mg tablets after discharge, and up until proper education and total cessation of PPIs, marginal hypomagnesemia, with serum magnesium level of 0.5mmol/L, persisted without any significant overt clinical manifestations. In this case report, we intend to highlight the importance of assessing for all possible electrolyte abnormalities in a patient presenting with neurological symptoms, relevance of taking a thorough drug history including all undocumented over-the-counter medications, and importance of patient education in the prevention of further episodes.
date: 2024-07
language: eng
short title: Proton Pump Inhibitor Induced Hypomagnesemia Causing Seizures
library catalog: PubMed
description: PMID: 39114244 PMCID: PMC11303836
pages: e64044

Cureus
type: Journal
volume: 16
identifier: DOI 10.7759/cureus.64044
number: 7
alternative: Cureus
identifier: ISSN 2168-8184

hypomagnesemia
type: Memo

Full Text
type: Attachment
item type: attachment
resource: Krishnan et al. - 2024 - Proton Pump Inhibitor Induced Hypomagnesemia Causi.pdf
date submitted: 2024-11-01 17:54:42
link mode: 1
type: application/pdf

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-01 17:54:41
link mode: 3
type: text/html

Gastrointestinal surgery, malabsorptive conditions, and postoperative hypocalcemia after neck surgery
type: Article
item type: journalArticle
is part of: Surgery
authors: Person
  surname: Passman
  given name: Jesse E.
authors: Person
  surname: Ginzberg
  given name: Sara
authors: Person
  surname: Gasior
  given name: Julia A.
authors: Person
  surname: Krumeich
  given name: Lauren
authors: Person
  surname: Brensinger
  given name: Colleen
authors: Person
  surname: Bader
  given name: Amanda
authors: Person
  surname: Hwang
  given name: Jasmine
authors: Person
  surname: Kelz
  given name: Rachel
authors: Person
  surname: Wachtel
  given name: Heather
link: Passman et al. - 2024 - Gastrointestinal surgery, malabsorptive conditions.pdf
link: PubMed entry
abstract: BACKGROUND: Postoperative hypocalcemia is a common complication of thyroid and parathyroid surgery. Patients with prior gastric bypass face increased risk of postoperative hypocalcemia, but the impact of other malabsorptive conditions is not well understood. In this study, we evaluated the relationship between multiple medical and surgical malabsorptive states and hypocalcemia after thyroid and parathyroid surgery. METHODS: We performed a retrospective cohort study of patients who underwent total thyroidectomy and/or parathyroidectomy in Optum's deidentified Clinformatics Data Mart Database (2004-2022). Patients were categorized as having surgical (foregut/midgut: gastrectomy, intestinal bypass, enterectomy, enterostomy, pancreatectomy, or hindgut: colectomy/colostomy) or medical (Crohn or Celiac disease) malabsorptive conditions. The primary outcomes were early (<7 days) and late (7-365 days) postoperative hypocalcemia. Logistic regression was performed to determine the associations between malabsorptive conditions and outcomes. RESULTS: Of 25,400 patients (56.9% total thyroidectomy, 40.8% parathyroidectomy, and 2.4% both procedures), 4.0% had a pre-existing malabsorptive condition. Early postoperative hypocalcemia occurred in 8.8% of patients, and late hypocalcemia in 18.3%. Thyroidectomy was associated with a greater likelihood of hypocalcemia than parathyroidectomy (odds ratio: 1.22; P < .001). Pancreatectomy was associated with twice the adjusted odds of postoperative hypocalcemia (odds ratio: 2.27; P = .031) across both procedures. Patients with prior foregut/midgut surgery were at higher risk after total thyroidectomy (odds ratio: 1.65, P = .002). This association was significant in late (odds ratio: 1.82, P < .001) rather than early hypocalcemia (odds ratio: 1.33, P = .175). Hindgut surgery and medical malabsorption did not demonstrate such associations. CONCLUSION: Prior foregut and midgut resections may predispose patients to postoperative hypocalcemia, pa…
date: 2024-10-28
language: eng
library catalog: PubMed
description: PMID: 39472261
pages: S0039-6060(24)00842-0

Surgery
type: Journal
identifier: DOI 10.1016/j.surg.2024.08.057
alternative: Surgery
identifier: ISSN 1532-7361

Passman et al. - 2024 - Gastrointestinal surgery, malabsorptive conditions.pdf
type: Attachment
item type: attachment
resource: Passman et al. - 2024 - Gastrointestinal surgery, malabsorptive conditions.pdf
type: application/pdf

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-01 17:56:00
link mode: 3
type: text/html

Education Research: Educating Child Neurology Residents About Psychogenic Nonepileptic Seizures: A Needs Assessment
type: Article
item type: journalArticle
is part of: Neurology. Education
authors: Person
  surname: Talai
  given name: Afsaneh
authors: Person
  surname: Freedman
  given name: Daniel A.
authors: Person
  surname: Albert
  given name: Dara V. F.
authors: Person
  surname: Pediatric Epilepsy Research Consortium
link: PubMed entry
link: Talai et al. - 2024 - Education Research Educating Child Neurology Resi.pdf
abstract: BACKGROUND AND OBJECTIVES: Psychogenic nonepileptic seizures (PNES) are difficult to differentiate from epileptic seizures (ES) even for neurologists who see these conditions frequently. This difficulty is due to overlapping semiologic findings between the 2 diagnoses. Previous studies have shown that trainees, including neurology trainees, are not accurate in differentiating PNES from ES. Neurologists often find the communication of PNES difficult. Despite these challenges, most programs do not have formal curricula for teaching PNES, and there are no standards for residency curricula in this topic. The aim of this study was to understand the gaps in resident education on PNES. METHODS: This study was accomplished through a needs assessment of current pediatric neurology residents and residency program directors (PDs). Two unique surveys were distributed, 1 for child neurology trainees and 1 for PDs. Questions were designed to understand trainees' self-reported knowledge, confidence, current education received, and desired teaching. Similarly for PDs, questions were designed to assess the state of education on PNES at their programs, sufficiency of education, and their desire for standardized curriculum. RESULTS: Sixty-eight trainees and 21 PDs responded to the survey. Approximately one-quarter of trainees reported neutral to low levels of confidence and 38% reported neutral to low levels of knowledge in caring for patients with PNES. Trainees reported that directing patients with PNES to appropriate management was the most challenging aspect of care, followed by communicating the diagnosis, with 60% and 46% reporting difficulty, respectively. Only 21% of residents felt their current PNES education needs no improvement. One-fifth of PDs felt their current PNES education is not sufficient, and all reported they would incorporate a standardized curriculum. Trainees reported preferring to learn about this topic through lectures and simulation, while PDs preferred onli…
date: 2024-03
language: eng
short title: Education Research
library catalog: PubMed
description: PMID: 39360154 PMCID: PMC11441745
pages: e200111

Neurology. Education
type: Journal
volume: 3
identifier: DOI 10.1212/NE9.0000000000200111
number: 1
alternative: Neurol Educ
identifier: ISSN 2771-9979

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-01 17:58:33
link mode: 3
type: text/html

Talai et al. - 2024 - Education Research Educating Child Neurology Resi.pdf
type: Attachment
item type: attachment
resource: Talai et al. - 2024 - Education Research Educating Child Neurology Resi.pdf
type: application/pdf

Results of a National Delphi consensus on the outpatient management of pediatric psychogenic nonepileptic seizures in the United States
type: Article
item type: journalArticle
is part of: Epilepsy & Behavior: E&B
authors: Person
  surname: Talai
  given name: Afsaneh
authors: Person
  surname: Freedman
  given name: Daniel A.
authors: Person
  surname: Trott
  given name: Kristen
authors: Person
  surname: Steenari
  given name: Maija R.
authors: Person
  surname: Plioplys
  given name: Sigita
authors: Person
  surname: Kimbley
  given name: Hillary
authors: Person
  surname: Maden Cohen
  given name: Jennifer
authors: Person
  surname: Tatachar
  given name: Priya
authors: Person
  surname: Albert
  given name: Dara V. F.
authors: Person
  surname: Pediatric Epilepsy Research Consortium
link: PubMed entry
link: Talai et al. - 2024 - Results of a National Delphi consensus on the outp.pdf
subject: FND
subject: Functional neurologic disorder
subject: Functional seizures
subject: Multidisciplinary clinic
subject: PNES
abstract: BACKGROUND AND OBJECTIVES: The purpose of this study was to develop national consensus based on expert opinion on the optimal outpatient care model of pediatric psychogenic nonepileptic seizures (PNES). METHODS: A core working group (CWG) within the PNES special interest group of the Pediatric Epilepsy Research Consortium was established. The CWG developed a rigorous scoring rubric to select experts in pediatric PNES within the United States of America and a three-round Delphi study was conducted to assess consensus on key components of the management of pediatric PNES in the outpatient setting. RESULTS: Eighteen experts representing neurology, psychology, psychiatry, social work and nursing participated in the study. Strong consensus was reached that the multidisciplinary clinic (MDC) model is the gold standard for the outpatient management of pediatric PNES. Consensus was obtained that a neurologist, psychologist and social worker are essential members of the MDC and in the setting of unlimited resources, psychiatry and nursing are also recommended. Further consensus was established on the roles of specific personnel, structure of the clinic, billing practices, trainee inclusion, patient inclusion and exclusion, and end of visit management. While consensus was reached that a new term should be developed for this diagnosis, consensus was not reached on the ideal term. DISCUSSION: Expert consensus was established for the multidisciplinary management of pediatric PNES in the outpatient setting. Specific recommendations were provided that can facilitate the development and implementation of MDCs in other institutions. Further prospective studies are warranted to validate this practice model.
date: 2024-10-17
language: eng
library catalog: PubMed
description: PMID: 39423723
pages: 110096

Epilepsy & Behavior: E&B
type: Journal
volume: 160
identifier: DOI 10.1016/j.yebeh.2024.110096
alternative: Epilepsy Behav
identifier: ISSN 1525-5069

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-01 17:59:10
link mode: 3
type: text/html

Talai et al. - 2024 - Results of a National Delphi consensus on the outp.pdf
type: Attachment
item type: attachment
resource: Talai et al. - 2024 - Results of a National Delphi consensus on the outp.pdf
type: application/pdf

Exacerbation of Psychogenic Non-epileptic Seizures Related to the Diagnosis and Disease Burden of Epilepsy: A Case Report
type: Article
item type: journalArticle
is part of: Cureus
  type: Journal
  volume: 16
  identifier: DOI 10.7759/cureus.68445
  number: 9
  alternative: Cureus
  identifier: ISSN 2168-8184
authors: Person
  surname: Kimura
  given name: Kenichi
authors: Person
  surname: Nakamura
  given name: Yuichi
authors: Person
  surname: Yokoyama
  given name: Kenki
authors: Person
  surname: Fujii
  given name: Yutaka
authors: Person
  surname: Horinouchi
  given name: Toru
link: Full Text
link: PubMed entry
subject: comorbid conditions
subject: conversion disorder
subject: disease burden
subject: epilepsy
subject: epileptic seizures
subject: psychoeducation
subject: psychogenic non-epileptic seizures
subject: psychological distress
subject: social stigma
abstract: Psychogenic non-epileptic seizures (PNES), which closely resemble epileptic seizures (ES), are typically triggered by psychological distress and represent the most prevalent form of conversion disorder encountered in clinical practice. Multiple physical conditions can both precipitate and sustain PNES episodes. Epilepsy, a common neurological disorder, imposes significant emotional and physical burdens, frequently resulting in elevated levels of anxiety and depression. This case report details the clinical course of a 19-year-old female whose PNES was exacerbated by the diagnosis and disease burden of epilepsy. The patient's background of childhood trauma, bullying, and sexual abuse likely predisposed her to the development of PNES. Upon receiving a diagnosis of epilepsy, characterized by focal seizures originating from the left parietal region, the patient experienced increased anxiety and required frequent hospitalizations. Despite adjustments to her treatment regimen, including the administration of levetiracetam (LEV) and lacosamide (LCM), her seizures persisted. Comprehensive evaluations, comprising electroencephalography (EEG) and single-photon emission computed tomography (SPECT), indicated the coexistence of epilepsy and PNES. Although surgical intervention was initially considered, it was ultimately deemed unnecessary, which subsequently alleviated the patient's anxiety. Psychoeducation highlighting the manageability of her epilepsy with ongoing pharmacotherapy significantly reduced her PNES episodes. This case emphasizes the critical role of addressing the psychosocial burden associated with an epilepsy diagnosis, as these factors may exacerbate PNES. It also underscores the importance of a holistic treatment approach that integrates psychological support with medical management.
date: 2024-09
language: eng
short title: Exacerbation of Psychogenic Non-epileptic Seizures Related to the Diagnosis and Disease Burden of Epilepsy
library catalog: PubMed
description: PMID: 39224495 PMCID: PMC11368020
pages: e68445

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resource: Kimura et al. - 2024 - Exacerbation of Psychogenic Non-epileptic Seizures.pdf
date submitted: 2024-11-01 18:01:10
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item type: attachment
date submitted: 2024-11-01 18:01:08
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Reversible dementia and seizures due to metformin-induced vitamin B12 deficiency
type: Article
item type: journalArticle
is part of: L'Encéphale
authors: Person
  surname: Laroussi
  given name: Sirine
authors: Person
  surname: Bouattour
  given name: Nadia
authors: Person
  surname: Daoud
  given name: Sawsan
authors: Person
  surname: Moalla
  given name: Khadija Sonda
authors: Person
  surname: Sakka
  given name: Salma
authors: Person
  surname: Damak
  given name: Mariem
authors: Person
  surname: Farhat
  given name: Nouha
authors: Person
  surname: Mhiri
  given name: Chokri
link: Laroussi et al. - 2024 - Reversible dementia and seizures due to metformin-.pdf
date: 08/2024
language: en
library catalog: DOI.org (Crossref)
date submitted: 2024-11-06 21:29:09
pages: 474-477

L'Encéphale
type: Journal
volume: 50
identifier: DOI 10.1016/j.encep.2023.11.030
number: 4
alternative: L'Encéphale
identifier: ISSN 00137006

Laroussi et al. - 2024 - Reversible dementia and seizures due to metformin-.pdf
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resource: Laroussi et al. - 2024 - Reversible dementia and seizures due to metformin-.pdf
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Diabetes mellitus: a risk factor for seizures in the elderly-a population-based study
type: Article
item type: journalArticle
is part of: Acta Diabetologica
authors: Person
  surname: Baviera
  given name: Marta
authors: Person
  surname: Roncaglioni
  given name: Maria Carla
authors: Person
  surname: Tettamanti
  given name: Mauro
authors: Person
  surname: Vannini
  given name: Tommaso
authors: Person
  surname: Fortino
  given name: Ida
authors: Person
  surname: Bortolotti
  given name: Angela
authors: Person
  surname: Merlino
  given name: Luca
authors: Person
  surname: Beghi
  given name: Ettore
link: Baviera et al. - 2017 - Diabetes mellitus a risk factor for seizures in t.pdf
link: PubMed entry
subject: Aged
subject: Aged, 80 and over
subject: Aging
subject: Comorbidity
subject: Diabetes Complications
subject: Diabetes mellitus
subject: Diabetes Mellitus
subject: Elderly
subject: Epilepsy
subject: Female
subject: Humans
subject: Hypoglycemic Agents
subject: Incidence
subject: Italy
subject: Male
subject: Risk Factors
subject: Seizures
abstract: AIMS: To evaluate the association between diabetes mellitus (DM) and risk of seizures in a well-defined elderly population. METHODS: The administrative databases of the Lombardy region (a 10 million population area in Northern Italy) were used to identify persons aged 65 years or older with DM (defined by prescription of antidiabetic drugs and/or through ICD-9 CM code and/or exemption code for diabetes) during the year 2002. Seizure-free DM subjects were followed until 2012 in search of individuals with incident seizures (identified through ICD-9 CM codes for epilepsy/seizures or ATC codes for antiepileptic drugs associated with the prescription of an electroencephalogram). To adjust for confounding, comorbidities having epileptogenic potential were also identified through the ICD-9 CM codes. RESULTS: The population at risk included 1,494,071 persons. Of these, 136,941 seizure-free patients had DM. At the end of follow-up, the cumulative time-dependent incidence of seizures was 3.0% in DM patients and 1.9% in No-diabetic individuals (hazard ratio, HR 1.47; 95% confidence interval, 1.41-1.53, adjusted for age classes, sex, comorbidities and number of hospital admission). The HR was unchanged in patients with no history of stroke. The cumulative incidence of seizures after DM increased with the number of hospital admissions. CONCLUSIONS: DM is an independent risk factor for seizures in elderly individuals. In diabetic patients, the risk of seizures increases with the number of comorbidities, supporting the role of vascular disease as a cause of seizures.
date: 2017-09
language: eng
short title: Diabetes mellitus
library catalog: PubMed
description: PMID: 28631057
pages: 863-870

Acta Diabetologica
type: Journal
volume: 54
identifier: DOI 10.1007/s00592-017-1011-0
number: 9
alternative: Acta Diabetol
identifier: ISSN 1432-5233

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resource: Baviera et al. - 2017 - Diabetes mellitus a risk factor for seizures in t.pdf
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item type: attachment
date submitted: 2024-11-06 23:43:56
link mode: 3
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Diagnosis and Management of Sodium Disorders: Hyponatremia and Hypernatremia
type: Article
item type: journalArticle
is part of: American Family Physician
authors: Person
  surname: Miller
  given name: Nathaniel E.
authors: Person
  surname: Rushlow
  given name: David
authors: Person
  surname: Stacey
  given name: Stephen K.
link: PubMed entry
subject: Humans
subject: Hypernatremia
subject: Hyponatremia
subject: Hypovolemia
subject: Sodium
subject: Water
abstract: Hyponatremia and hypernatremia are electrolyte disorders that can be associated with poor outcomes. Hyponatremia is considered mild when the sodium concentration is 130 to 134 mEq per L, moderate when 125 to 129 mEq per L, and severe when less than 125 mEq per L. Mild symptoms include nausea, vomiting, weakness, headache, and mild neurocognitive deficits. Severe symptoms of hyponatremia include delirium, confusion, impaired consciousness, ataxia, seizures, and, rarely, brain herniation and death. Patients with a sodium concentration of less than 125 mEq per L and severe symptoms require emergency infusions with 3% hypertonic saline. Using calculators to guide fluid replacement helps avoid overly rapid correction of sodium concentration, which can cause osmotic demyelination syndrome. Physicians should identify the cause of a patient's hyponatremia, if possible; however, treatment should not be delayed while a diagnosis is pursued. Common causes include certain medications, excessive alcohol consumption, very low-salt diets, and excessive free water intake during exercise. Management to correct sodium concentration is based on whether the patient is hypovolemic, euvolemic, or hypervolemic. Hypovolemic hyponatremia is treated with normal saline infusions. Treating euvolemic hyponatremia includes restricting free water consumption or using salt tablets or intravenous vaptans. Hypervolemic hyponatremia is treated primarily by managing the underlying cause (e.g., heart failure, cirrhosis) and free water restriction. Hypernatremia is less common than hyponatremia. Mild hypernatremia is often caused by dehydration resulting from an impaired thirst mechanism or lack of access to water; however, other causes, such as diabetes insipidus, are possible. Treatment starts with addressing the underlying etiology and correcting the fluid deficit. When sodium is severely elevated, patients are symptomatic, or intravenous fluids are required, hypotonic fluid replacement is necessary.
date: 2023-11
language: eng
short title: Diagnosis and Management of Sodium Disorders
library catalog: PubMed
description: PMID: 37983699
pages: 476-486

American Family Physician
type: Journal
volume: 108
number: 5
alternative: Am Fam Physician
identifier: ISSN 1532-0650

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type: Attachment
item type: attachment
date submitted: 2024-11-06 23:49:57
link mode: 3
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Dementia in Diabetes: The Role of Hypoglycemia
type: Article
item type: journalArticle
is part of: International Journal of Molecular Sciences
  type: Journal
  volume: 24
  identifier: DOI 10.3390/ijms24129846
  number: 12
  alternative: Int J Mol Sci
  identifier: ISSN 1422-0067
authors: Person
  surname: Husain
  given name: Khaled Hameed
authors: Person
  surname: Sarhan
  given name: Saud Faisal
authors: Person
  surname: AlKhalifa
  given name: Haya Khaled Ali Abdulla
authors: Person
  surname: Buhasan
  given name: Asal
authors: Person
  surname: Moin
  given name: Abu Saleh Md
authors: Person
  surname: Butler
  given name: Alexandra E.
link: Full Text
link: PubMed entry
subject: Alzheimer’s disease
subject: Blood Glucose
subject: cognition
subject: dementia
subject: Dementia
subject: diabetes
subject: Diabetes Mellitus, Type 2
subject: Humans
subject: hypoglycemia
subject: Hypoglycemia
subject: Hypoglycemic Agents
subject: insulin
subject: Risk Factors
abstract: Hypoglycemia, a common consequence of diabetes treatment, is associated with severe morbidity and mortality and has become a major barrier to intensifying antidiabetic therapy. Severe hypoglycemia, defined as abnormally low blood glucose requiring the assistance of another person, is associated with seizures and comas, but even mild hypoglycemia can cause troubling symptoms such as anxiety, palpitations, and confusion. Dementia generally refers to the loss of memory, language, problem-solving, and other cognitive functions, which can interfere with daily life, and there is growing evidence that diabetes is associated with an increased risk of both vascular and non-vascular dementia. Neuroglycopenia resulting from a hypoglycemic episode in diabetic patients can lead to the degeneration of brain cells, with a resultant cognitive decline, leading to dementia. In light of new evidence, a deeper understating of the relationship between hypoglycemia and dementia can help to inform and guide preventative strategies. In this review, we discuss the epidemiology of dementia among patients with diabetes, and the emerging mechanisms thought to underlie the association between hypoglycemia and dementia. Furthermore, we discuss the risks of various pharmacological therapies, emerging therapies to combat hypoglycemia-induced dementia, as well as risk minimization strategies.
date: 2023-06-07
language: eng
short title: Dementia in Diabetes
library catalog: PubMed
description: PMID: 37372995 PMCID: PMC10298520
pages: 9846

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resource: Husain et al. - 2023 - Dementia in Diabetes The Role of Hypoglycemia.pdf
date submitted: 2024-11-06 23:50:48
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item type: attachment
date submitted: 2024-11-06 23:50:46
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Seizures as a clinical manifestation in somatic autoimmune disorders
type: Article
item type: journalArticle
is part of: Seizure
authors: Person
  surname: Amanat
  given name: Man
authors: Person
  surname: Thijs
  given name: Roland D.
authors: Person
  surname: Salehi
  given name: Mona
authors: Person
  surname: Sander
  given name: Josemir W.
link: Full Text
link: PubMed entry
subject: Autoimmune Diseases
subject: Comorbidity
subject: Cytokines
subject: Epilepsy
subject: Humans
subject: Lupus erythematosus
subject: Seizures
subject: Type 1 diabetes mellitus
abstract: The risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto's encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and antibodies against neuronal antigens may contribute to the etiopathogenesis of seizures and epilepsy associated to immune conditions. Other unknown factors, the effect of different co-morbid conditions of epilepsy as well as shared risk factors such as common etiological factors, environmental triggers, or a common genetic predisposition may also explain the association. We review different autoimmune disorders which may present with co-morbid seizures and discuss possible underlying mechanisms of this co-occurrence focusing on a potential role of immune system dysfunction.
date: 2019-01
language: eng
library catalog: PubMed
description: PMID: 30562654
pages: 59-64

Seizure
type: Journal
volume: 64
identifier: DOI 10.1016/j.seizure.2018.11.012
alternative: Seizure
identifier: ISSN 1532-2688

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item type: attachment
resource: Amanat et al. - 2019 - Seizures as a clinical manifestation in somatic au.pdf
date submitted: 2024-11-07 00:00:42
link mode: 1
type: application/pdf

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item type: attachment
date submitted: 2024-11-07 00:00:40
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Relation of Serum Magnesium Level in Adult Patients with Idiopathic Generalized Epilepsy in a Tertiary Care Hospital
type: Article
item type: journalArticle
is part of: Mymensingh medical journal: MMJ
authors: Person
  surname: Ahmed
  given name: F.
authors: Person
  surname: Bhattacharjee
  given name: M.
authors: Person
  surname: Saiduzzaman
  given name: M.
authors: Person
  surname: Rahman
  given name: S. S.
authors: Person
  surname: Mia
  given name: E.
authors: Person
  surname: Banerjee
  given name: S.
authors: Person
  surname: Linckon
  given name: M. K.
is referenced by: item 90
link: PubMed entry
subject: Adult
subject: Bangladesh
subject: Case-Control Studies
subject: Cross-Sectional Studies
subject: Epilepsy, Generalized
subject: Female
subject: Humans
subject: Magnesium
subject: Male
subject: Middle Aged
subject: Tertiary Care Centers
subject: Young Adult
abstract: Magnesium plays a vast role in the nervous system. In particular, high magnesium in cerebrospinal fluid appears to enhance the neural functions, while low magnesium induces neuronal diseases. The aim of the study was to find out the relation of serum magnesium with idiopathic generalized epilepsy attending in a tertiary care hospital. This cross-sectional comparative study was conducted in the department of Neurology at Mymensingh Medical College and Hospital, Bangladesh from January 2019 to June 2020 following ethical approval. Total 110 purposively selected participants (55 with idiopathic generalized epilepsy and 55 non epileptic apparently healthy individuals) were enrolled in this study. Serum total Mg was measured by EMP-168 Biochemical Analyzer. Average age of epileptic individuals was 33.13±9.5 years and majority was female (60.0%). Mean serum magnesium level was lower in epileptic patients than controls (1.80±0.041 vs. 2.02±0.19 mg/dl; p<0.001). Patients with higher seizure attack (>3 per month) had significantly lower mean serum magnesium level than the patients with seizure attack three or less per month. Serum magnesium levels are reduced in epileptic patients compared to healthy age and gender matched controls. Studies involving larger numbers of patients are needed to confirm these results.
date: 2024-10
language: eng
library catalog: PubMed
description: PMID: 39351716
pages: 996-1001

Mymensingh medical journal: MMJ
type: Journal
volume: 33
number: 4
alternative: Mymensingh Med J
identifier: ISSN 2408-8757

item 90
type: Memo
value: Abstract Magnesium plays a vast role in the nervous system. In particular, high magnesium in cerebrospinal fluid appears to enhance the neural functions, while low magnesium induces neuronal diseases. The aim of the study was to find out the relation of serum magnesium with idiopathic generalized epilepsy attending in a tertiary care hospital. This cross-sectional comparative study was conducted in the department of Neurology at Mymensingh Medical College and Hospital, Bangladesh from January 2019 to June 2020 following ethical approval. Total 110 purposively selected participants (55 with idiopathic generalized epilepsy and 55 non epileptic apparently healthy individuals) were enrolled in this study. Serum total Mg was measured by EMP-168 Biochemical Analyzer. Average age of epileptic individuals was 33.13±9.5 years and majority was female (60.0%). Mean serum magnesium level was lower in epileptic patients than controls (1.80±0.041 vs. 2.02±0.19 mg/dl; p<0.001). Patients with higher seizure attack (>3 per month) had significantly lower mean serum magnesium level than the patients with seizure attack three or less per month. Serum magnesium levels are reduced in epileptic patients compared to healthy age and gender matched controls. Studies involving larger numbers of patients are needed to confirm these results.

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date submitted: 2024-11-07 00:04:58
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Role of Magnesium in Skeletal Muscle Health and Neuromuscular Diseases: A Scoping Review
type: Article
item type: journalArticle
is part of: International Journal of Molecular Sciences
  type: Journal
  volume: 25
  identifier: DOI 10.3390/ijms252011220
  number: 20
  alternative: Int J Mol Sci
  identifier: ISSN 1422-0067
authors: Person
  surname: Liguori
  given name: Sara
authors: Person
  surname: Moretti
  given name: Antimo
authors: Person
  surname: Paoletta
  given name: Marco
authors: Person
  surname: Gimigliano
  given name: Francesca
authors: Person
  surname: Iolascon
  given name: Giovanni
link: Liguori et al. - 2024 - Role of Magnesium in Skeletal Muscle Health and Ne.pdf
link: PubMed entry
subject: Animals
subject: dietary supplement
subject: Dietary Supplements
subject: Humans
subject: magnesium
subject: Magnesium
subject: muscle strength
subject: Muscle, Skeletal
subject: neuromuscular disease
subject: Neuromuscular Diseases
subject: skeletal muscle
abstract: Magnesium (Mg) is a vital element for various metabolic and physiological functions in the human body, including its crucial role in skeletal muscle health. Hypomagnesaemia is frequently reported in many muscle diseases, and it also seems to contribute to the pathogenesis of skeletal muscle impairment in patients with neuromuscular diseases. The aim of this scoping review is to analyze the role of Mg in skeletal muscle, particularly its biological effects on muscle tissue in neuromuscular diseases (NMDs) in terms of biological effects and clinical implications. This scoping review followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. From the 305 studies identified, 20 studies were included: 4 preclinical and 16 clinical studies. Preclinical research has demonstrated that Mg plays a critical role in modulating pathways affecting skeletal muscle homeostasis and oxidative stress in muscles. Clinical studies have shown that Mg supplementation can improve muscle mass, respiratory muscle strength, and exercise recovery and reduce muscle soreness and inflammation in athletes and patients with various conditions. Despite the significant role of Mg in muscle health, there is a lack of research on Mg supplementation in NMDs. Given the potential similarities in pathogenic mechanisms between NMDs and Mg deficiency, further studies on the effects of Mg supplementation in NMDs are warranted. Overall, maintaining optimal Mg levels through dietary intake or supplementation may have important implications for improving muscle health and function, particularly in conditions associated with muscle weakness and atrophy.
date: 2024-10-18
language: eng
short title: Role of Magnesium in Skeletal Muscle Health and Neuromuscular Diseases
library catalog: PubMed
description: PMID: 39457008 PMCID: PMC11508242
pages: 11220

Liguori et al. - 2024 - Role of Magnesium in Skeletal Muscle Health and Ne.pdf
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resource: Liguori et al. - 2024 - Role of Magnesium in Skeletal Muscle Health and Ne.pdf
type: application/pdf

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item type: attachment
date submitted: 2024-11-07 00:27:55
link mode: 3
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Hyponatremia-Induced Epileptic Seizure Provoked by Levetiracetam and Pain Medication Intake in a Patient with Central Diabetes Insipidus
type: Article
item type: journalArticle
is part of: Case Reports in Neurology
authors: Person
  surname: Nägele
  given name: Herbert
authors: Person
  surname: Rosenkranz
  given name: Michael
authors: Person
  surname: Nägele
  given name: Matthias P.
link: Full Text
link: PubMed entry
subject: Diabetes insipidus
subject: Epilepsy
subject: Hyponatremia
subject: Levetiracetam
subject: Syndrome of inappropriate antidiuretic hormone
abstract: INTRODUCTION: Causes of epileptic seizures are often multifactorial but for an effective therapy, they should be uncovered in detail. CASE PRESENTATION: We present a 67-year-old male patient with a central diabetes insipidus, who experienced a generalized tonic-clonic seizure. The patient was treated with levetiracetam for prevention of further seizures, opioids and non-steroidal anti-inflammatory drugs, i.e., ibuprofen because of severe back pain due to vertebral compression fractures. In this setting, he developed significant hyponatremia and experienced another epileptic seizure. After stopping analgesics and switching from levetiracetam to lacosamide, sodium levels returned to normal and the patient remained free of seizures since then. CONCLUSION: The interrelationships of medical therapy, sodium levels and epileptic seizures in the context of central diabetes insipidus are discussed.
date: 2024
language: eng
library catalog: PubMed
description: PMID: 39145134 PMCID: PMC11324277
pages: 204-207

Case Reports in Neurology
type: Journal
volume: 16
identifier: DOI 10.1159/000540320
number: 1
alternative: Case Rep Neurol
identifier: ISSN 1662-680X

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item type: attachment
resource: Nägele et al. - 2024 - Hyponatremia-Induced Epileptic Seizure Provoked by.pdf
date submitted: 2024-11-07 00:59:31
link mode: 1
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date submitted: 2024-11-07 00:59:28
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Short-Term Outcomes of Patients With Hyponatremia Presenting to the Emergency Department: An Observational Study
type: Article
item type: journalArticle
is part of: Cureus
  type: Journal
  volume: 16
  identifier: DOI 10.7759/cureus.63679
  number: 7
  alternative: Cureus
  identifier: ISSN 2168-8184
authors: Person
  surname: Shekar
  given name: Rakesh G.
authors: Person
  surname: Rodha
  given name: Mahaveer Singh
authors: Person
  surname: Sharma
  given name: Ankur
authors: Person
  surname: Rohila
  given name: Amit
authors: Person
  surname: Shukla
  given name: Kamla Kant
authors: Person
  surname: Choudhary
  given name: Rahul
authors: Person
  surname: Bohra
  given name: Gopal K.
link: PubMed entry
link: Shekar et al. - 2024 - Short-Term Outcomes of Patients With Hyponatremia .pdf
subject: emergency
subject: hyponatremia
subject: icu
subject: mortality
subject: sodium
abstract: BACKGROUND: Hyponatremia is the predominant electrolyte imbalance disorder in the emergency department. It can manifest with a diverse array of symptoms, ranging from non-specific and moderate to severe and even life-threatening. There is a scarcity of literature addressing the clinical characteristics and prognosis of patients with hyponatremia presenting to the emergency department in the western part of Rajasthan. The objective of this study was to investigate the impact of hyponatremia on the outcomes of patients presenting to the emergency department. METHODS: In this prospective, cross-sectional, observational study, 200 patients aged more than 18 years who presented to the emergency department with serum sodium < 135 mEq/l were included. The triage of patients was determined by their primary complaints. The primary outcome was to study the clinical profile of patients with hyponatremia presenting to the emergency department. The secondary outcomes were to examine the etiology, i.e., hypovolemic, euvolemic, or hypervolemic, and the outcome of patients on the 7th day (patient admitted to the ward or intensive care unit) and the 28th day (discharged or death) with hyponatremia presenting to the emergency department. The clinical status of the patients was noted by telephonic follow-up in case they were not admitted for this period. RESULTS: Out of 200 patients, 66 (33%) had hypovolemic, 96 (48%) had euvolemic, and 38 (19%) had hypervolemic hyponatremia. We observed that seizures (84.2%), confusion (56%), and coma (77.7%) were the most common clinical features of patients with severe hyponatremia in the emergency, which was statistically significant than mild and moderate hyponatremia (p = 0.03, 0.023, and 0.029, respectively). On the 7th day of hospitalization, out of 181 (90.5%) admissions in the ward, 116 (64.08%) had severe hyponatremia, and out of 19 (9.5%) ICU admissions, 13 (68.4%) had severe hyponatremia. Death was seen in five (2.5%) patients, one (20%) …
date: 2024-07
language: eng
short title: Short-Term Outcomes of Patients With Hyponatremia Presenting to the Emergency Department
library catalog: PubMed
description: PMID: 39092320 PMCID: PMC11293598
pages: e63679

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type: Attachment
item type: attachment
date submitted: 2024-11-07 01:01:48
link mode: 3
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item type: attachment
resource: Shekar et al. - 2024 - Short-Term Outcomes of Patients With Hyponatremia .pdf
type: application/pdf

Prevalence of hyponatremia among medically hospitalized patients and associated outcomes: a retrospective cohort study
type: Article
item type: journalArticle
is part of: Annals of Saudi Medicine
authors: Person
  surname: Al Yaqoubi
  given name: Intisar Hamood
authors: Person
  surname: Al-Maqbali
  given name: Juhaina Salim
authors: Person
  surname: Al Farsi
  given name: Afnan Ahmed
authors: Person
  surname: Al Jabri
  given name: Rayan Khalfan
authors: Person
  surname: Khan
  given name: Saif Ahmed
authors: Person
  surname: Al Alawi
  given name: Abdullah M.
link: Full Text
link: PubMed entry
subject: Adult
subject: Age Factors
subject: Aged
subject: Aged, 80 and over
subject: Cohort Studies
subject: Female
subject: Hospital Mortality
subject: Hospitalization
subject: Humans
subject: Hyponatremia
subject: Length of Stay
subject: Male
subject: Middle Aged
subject: Patient Readmission
subject: Prevalence
subject: Retrospective Studies
subject: Risk Factors
subject: Severity of Illness Index
subject: Sodium
subject: Tertiary Care Centers
abstract: BACKGROUND: Hyponatremia is a common electrolyte disturbance among hospitalized patients and is linked to increased mortality as well as poor outcomes. OBJECTIVES: Study the prevalence of hyponatremia among medically admitted patients and the outcomes associated with hyponatremia. DESIGN: Retrospective cohort. SETTING: Medical ward at tertiary hospital setting. PATIENTS AND METHODS: The study included adult (≥18 years) hospitalized patients in general medical wards. Three readings of serum sodium level were taken (initial sodium level, nadir during admission, and before discharge). SAMPLE SIZE AND BASIS: The sample size of 350 was determined based on a presumed 35% incidence of hyponatremia among hospitalized patients, with a 5% error margin. MAIN OUTCOME MEASURES: The prevalence of hyponatremia among medically hospitalized patients and association with health outcomes including length of hospital stay, inpatient mortality, 90-days readmission and 1-year mortality. RESULTS: In this study, 736 patients met the inclusion criteria. Of these, 377 (51.2%) had hyponatremia on admission, increasing to 562 (76.35%) during hospitalization. Mild hyponatremia was observed in 49.6% (n=365), moderate in 13.6% (n=100), and severe in 13.2% (n=97). Severe hyponatremia patients were significantly older (P<.01), predominantly female (P=.014), and had lower serum magnesium and albumin levels (P<.01). Hypertension, ischemic heart disease, heart failure, and diabetes were more prevalent in severe hyponatremia cases (P<.01, P<.01, P=.045, P<.01, respectively). Hospital stays were significantly shorter for patients with normal sodium levels (P<.01). Patients with severe hyponatremia had a shorter time for first hospital readmission (HR=0.80, P<.01 [95% CI; 0.69-0.94]). CONCLUSION: Hyponatremia was prevalent among medically hospitalized patients and more common among old patients, women, and patients with comorbidities. Hyponatremia was associated with increased length of stay in hospital …
date: 2024
language: eng
short title: Prevalence of hyponatremia among medically hospitalized patients and associated outcomes
library catalog: PubMed
description: PMID: 39368118 PMCID: PMC11454974
pages: 339-348

Annals of Saudi Medicine
type: Journal
volume: 44
identifier: DOI 10.5144/0256-4947.2024.339
number: 5
alternative: Ann Saudi Med
identifier: ISSN 0975-4466

Full Text
type: Attachment
item type: attachment
resource: Al Yaqoubi et al. - 2024 - Prevalence of hyponatremia among medically hospita.pdf
date submitted: 2024-11-07 01:17:13
link mode: 1
type: application/pdf

PubMed entry
type: Attachment
item type: attachment
date submitted: 2024-11-07 01:17:09
link mode: 3
type: text/html

Seizure Paper
type: Collection
has part: betus
has part: electrolytes
has part: etoh
has part: meds
has part: Used Seizures
has part: Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes.
has part: Seizure occurrences among hypoglycemic patients in the emergency department
has part: Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management
has part: Disney to Pixar Transition Causing Epilepsy: A Case Report of Reflex Epilepsy
has part: Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation—Structured Literature Review and Analysis
has part: Imipenem-Cilastatin-Induced Seizures: A Case Report
has part: Fluoroquinolones and the risk for incidental seizures: a comparative retrospective study
has part: Antibiotic-induced neuropsychiatric toxicity: epidemiology, mechanisms and management strategies –a narrative literature review
has part: Cefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit
has part: Clinical characteristics of seizure recurrence and epilepsy development in patients with alcohol‐related seizures
has part: Subacute encephalopathy with seizures in alcoholics (SESA) syndrome: Relevant questions
has part: Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data?
has part: Seizures provoked by over-the-counter cough and cold medications in an elderly patient: a case report
has part: Caffeine exacerbates seizure-induced death via postictal hypoxia
has part: Hypocalcemia‐induced seizures in a peritoneal dialysis ( PD ) patient: A case report
has part: Association of dietary fiber intake with epileptic seizures in U.S. adults: A Population-base study of 13,277 participants
has part: Clinical characteristics and serum 25-hydroxyvitamin D levels in children with febrile seizures in China
has part: Febrile Seizures, Ongoing Epileptiform Activity, and the Resulting Long-Term Consequences: Lessons From Animal Models
has part: A Very Rare Side Effect of a Very Commonly Used Drug: Pantoprazole-induced Seizure
has part: Vitamin B12 Deficiency Newborn Screening
has part: Seizure and Takotsubo Cardiomyopathy Due to Proton Pump Inhibitor
has part: Proton Pump Inhibitor Induced Hypomagnesemia Causing Seizures: A Rare Adverse Effect of a Commonly Used Medication
has part: Gastrointestinal surgery, malabsorptive conditions, and postoperative hypocalcemia after neck surgery
has part: Education Research: Educating Child Neurology Residents About Psychogenic Nonepileptic Seizures: A Needs Assessment
has part: Results of a National Delphi consensus on the outpatient management of pediatric psychogenic nonepileptic seizures in the United States
has part: Exacerbation of Psychogenic Non-epileptic Seizures Related to the Diagnosis and Disease Burden of Epilepsy: A Case Report
has part: Reversible dementia and seizures due to metformin-induced vitamin B12 deficiency
has part: Diagnosis and Management of Sodium Disorders: Hyponatremia and Hypernatremia
has part: Dementia in Diabetes: The Role of Hypoglycemia
has part: Seizures as a clinical manifestation in somatic autoimmune disorders
has part: Relation of Serum Magnesium Level in Adult Patients with Idiopathic Generalized Epilepsy in a Tertiary Care Hospital
has part: Hyponatremia-Induced Epileptic Seizure Provoked by Levetiracetam and Pain Medication Intake in a Patient with Central Diabetes Insipidus

betus
type: Collection
has part: Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes.
has part: Seizure occurrences among hypoglycemic patients in the emergency department
has part: Dementia in Diabetes: The Role of Hypoglycemia

electrolytes
type: Collection
has part: Hypocalcemia‐induced seizures in a peritoneal dialysis ( PD ) patient: A case report
has part: Association of dietary fiber intake with epileptic seizures in U.S. adults: A Population-base study of 13,277 participants
has part: Clinical characteristics and serum 25-hydroxyvitamin D levels in children with febrile seizures in China
has part: A Very Rare Side Effect of a Very Commonly Used Drug: Pantoprazole-induced Seizure
has part: Vitamin B12 Deficiency Newborn Screening
has part: Seizure and Takotsubo Cardiomyopathy Due to Proton Pump Inhibitor
has part: Proton Pump Inhibitor Induced Hypomagnesemia Causing Seizures: A Rare Adverse Effect of a Commonly Used Medication
has part: Gastrointestinal surgery, malabsorptive conditions, and postoperative hypocalcemia after neck surgery
has part: Role of Magnesium in Skeletal Muscle Health and Neuromuscular Diseases: A Scoping Review
has part: Hyponatremia-Induced Epileptic Seizure Provoked by Levetiracetam and Pain Medication Intake in a Patient with Central Diabetes Insipidus
has part: Short-Term Outcomes of Patients With Hyponatremia Presenting to the Emergency Department: An Observational Study
has part: Prevalence of hyponatremia among medically hospitalized patients and associated outcomes: a retrospective cohort study

etoh
type: Collection
has part: Clinical characteristics of seizure recurrence and epilepsy development in patients with alcohol‐related seizures
has part: Subacute encephalopathy with seizures in alcoholics (SESA) syndrome: Relevant questions

meds
type: Collection
has part: Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation—Structured Literature Review and Analysis
has part: Imipenem-Cilastatin-Induced Seizures: A Case Report
has part: Fluoroquinolones and the risk for incidental seizures: a comparative retrospective study
has part: Antibiotic-induced neuropsychiatric toxicity: epidemiology, mechanisms and management strategies –a narrative literature review
has part: Cefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit
has part: Seizures provoked by over-the-counter cough and cold medications in an elderly patient: a case report
has part: A Very Rare Side Effect of a Very Commonly Used Drug: Pantoprazole-induced Seizure
has part: Proton Pump Inhibitor Induced Hypomagnesemia Causing Seizures: A Rare Adverse Effect of a Commonly Used Medication
has part: Reversible dementia and seizures due to metformin-induced vitamin B12 deficiency

Used Seizures
type: Collection
has part: Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation—Structured Literature Review and Analysis
has part: Antibiotic-induced neuropsychiatric toxicity: epidemiology, mechanisms and management strategies –a narrative literature review
has part: Cefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit
has part: Seizures provoked by over-the-counter cough and cold medications in an elderly patient: a case report
has part: Hypocalcemia‐induced seizures in a peritoneal dialysis ( PD ) patient: A case report
has part: Association of dietary fiber intake with epileptic seizures in U.S. adults: A Population-base study of 13,277 participants
has part: Clinical characteristics and serum 25-hydroxyvitamin D levels in children with febrile seizures in China
has part: Proton Pump Inhibitor Induced Hypomagnesemia Causing Seizures: A Rare Adverse Effect of a Commonly Used Medication
has part: Gastrointestinal surgery, malabsorptive conditions, and postoperative hypocalcemia after neck surgery
has part: Reversible dementia and seizures due to metformin-induced vitamin B12 deficiency
has part: Dementia in Diabetes: The Role of Hypoglycemia